FSOA-2019-0027ga.docx (209.87 kB)
Download fileGraphical Abstract - Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis
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posted on 2020-02-27, 11:08 authored by Mohd Sajjad Ahmad Khan, Fatimah Alshehrei, Saleh Bakheet Al-Ghamdi, Majid Abdullah Bamaga, Abdullah Safar Al-Thubiani, Mohammad Zubair AlamGraphical abstract: Candida
albicans has remained the main etiological agent of candidiasis, challenges
clinicians with high mortality and morbidity. The emergence of resistance to
antifungal drugs, toxicity and lower efficacy have all contributed to an urgent
need to develop alternative drugs aiming at novel targets in C. albicans.
Targeting the production of virulence factors, which are essential processes
for infectious agents, represents an attractive substitute for the development
of newer anti-infectives. The present review highlights the recent developments
made in the understanding of the pathogenicity of C. albicans. Production of
hydrolytic enzymes, morphogenesis and biofilm formation, along with their
molecular and metabolic regulation in Candida are discussed with regard to the
development of novel anti-pathogenic drugs against candidiasis.