Supplementarytable 1. Empty SEP and DEP do not induce
relevant immune activation. MFI
of the activation marker CD25, CD80 expression by monocytes, and cytokine
levels in the culture supernatant following incubation of PBMCs with control DEP
and control SEP. Concentrations are equivalent to the lowest and highest
tested concentrations of the R848-loaded NPs, respectively. Mean ± SD of at
least three independent experiments; *all replicates below lower limit of
quantitation, as determined by Legendplex Software
Funding
This work was supported by the Deutsche Forschungsgemeinschaft (DFG) (GO1100/4-1), the Collaborative Research Center SFB 1278 "PolyTarget” project number 316213987 A06 (KDJ), and SFB Transregio 94 “Innate Immunity of the lung” project A02 (HH). We gratefully acknowledge the additional support of the Deutsche Forschungsgemeinschaft (DFG), grant references INST 275/389-1 FUGG; AOBJ: 640980 (KDJ).