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epi-2021-0077 Supplementary Tables 1–8 & Supplementary Figures 1–4

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posted on 30.07.2021, 08:35 by Figshare Future Science GroupFigshare Future Science Group, G.J.L.J. Snijders, Nina Notman, Amber Berdenis van Berlekom, Marjolein A. M. Sneeboer, Lotte C. Houtepen, Danny M. Nispeling, Yujie He, Stella Dracheva, Elly M. Hol, René S. Kahn Lot D. de Witte, Marco P. Boks

Supplementary table 1: Extended clinocopathological information of donors.

Supplementary table 2: Primers sequences for qPCR analyses.

Supplementary table 3: Geomean of raw CT values of reference genes beta-actin (βactin), Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and Succinate Dehydrogenase Complex Flavoprotein Subunit A (SDHA) for each donor and each tissue included in the gene-expression analysis.

Supplementary table 4: Associations between potential confounding variables sex, age, PMD, pH, Braak-score for gene-expression data.

Supplementary figure 1: QQ plot of the p-values from discovery EWAS.

Supplementary table 5: Results of the linear mixed-effects model of DNA methylation and the interaction term.

Supplementary table 6: Mean methylation values. Methylation values per DMR of SCZ and CTR samples, separated for grey and white matter.

Supplementary figure 2: Genome information of the four DMRs of interest.

Supplementary table 7: Outcome variables for gene-expression data.

Supplementary figure 3: Association between gene expression and DMR methylation in grey and white matter of the GFM and GTS in SCZ and CTR.

Supplementary figure 4: Principal component analysis of the DMR methylation changes.

Supplementary table 8: Overlap with CPGs or DMRs in previous genome-wide DNA methylation studies of SCZ.

Funding

S.D. is supported by VA Merit grant I01BX002876 and by NIH/NIMH U01MH116442

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