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Poly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer phototherapy - Supplementary dataset

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posted on 2023-02-21, 12:01 authored by Catia G Alves, Rita Lima-Sousa, Bruna L Melo, Paula Ferreira, Andre F Moreira, Ilıdio J Correia, Duarte de Melo-Diogo

Aims: To address the limitations of IR780 by preparing hydrophilic polymer–IR780 conjugates and to

employ these conjugates in the assembly of nanoparticles (NPs) intended for cancer photothermal

therapy. Materials & methods: The cyclohexenyl ring of IR780 was conjugated for the first time with

thiol-terminated poly(2-ethyl-2-oxazoline) (PEtOx). This novel poly(2-ethyl-2-oxazoline)-IR780 (PEtOx-

IR) conjugate was combined with D-α-tocopheryl succinate (TOS), leading to the assembly of mixed

NPs (PEtOx-IR/TOS NPs). Results: PEtOx-IR/TOS NPs displayed optimal colloidal stability as well as

cytocompatibility in healthy cells at doses within the therapeutic range. In turn, the combination of

PEtOx-IR/TOS NPs and near-infrared light reduced heterotypic breast cancer spheroid viability to just 15%.

Conclusion: PEtOx-IR/TOS NPs are promising agents for breast cancer photothermal therapy.

Funding

Fundação para a Ciência e a Tecnologia, (Grant / Award Number:'2021.00590.CEECIND','2021.06044.BD','2022.06320.PTDC ','PTDC/BTA-BTA/0696/2020 ','SFRH/BD/144922/2019 ','SFRH/BD/145386/2019','UIDB/00709/2020','UIDP/00709/2020')

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    Nanomedicine

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    Keywords

    cancerphotothermal therapypoly(2-ethyl-2-oxazoline)polymer–IR780 conjugatespheroids

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