Association between Human Herpesvirus-6 and Primary Brain Tumors: a systematic review and meta-analysis: Supplementary Data

dataset

posted on 2022-04-12, 13:17 authored by Saied Ghorbani, Arash Letafati, Alireza Khatami, Rana farzi, Soha Shabani, Pouya Moradi, Vahid Tambrchi, Hassan Saadati, Saher Papizadeh, Mona Vasei rad, Raheleh Tabatabaei, Saeed Bahadory, Ahmad Tavakoli, Farah Bokharaei-Salim, Seyed Hamidreza Monavari, Maryam Fatemipour, Mahdieh hoseini, Seyed Jalal Kiani

Supplementary Table 1. Search strategy

Supplementary Table 2. Quality assessment of included studies.

Supplementary figures

Supplementary Figure 1: Funnel plots before (A) and after (B) applying the trim-and-fill method. The open dots indicate the observed studies, and the closed dots indicate the missing studies imputed by the trim-and-fill method.

Supplementary Figure 2. The pooled prevalence of HHV-6 among primary brain cancer patients based on study type. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

Supplementary Figure 3. The pooled prevalence of HHV-6 among primary brain cancer patients based on Detection method. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

PCR: polymerase chain reaction, ELISA: enzyme-linked immunosorbent assay, NGS: next generation sequencing, ISH: in situ hybridization, IHC: immunohistochemistry

Supplementary Figure 4. The pooled prevalence of HHV-6 among primary brain cancer patients based on sample type. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

FFPE: Formalin-Fixed Paraffin-Embedded

Supplementary Figure 5. The pooled prevalence of HHV-6 among primary brain cancer patients based on geographical area. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

Supplementary Figure 6. Overall Association between HHV-6 and primary brain cancer. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

Supplementary Figure 7. Association between HHV-6 and primary brain cancer based on detection method. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

PCR: polymerase chain reaction, ISH: in situ hybridization, IHC: immunohistochemistry

Supplementary Figure 8. Association between HHV-6 and primary brain cancer based on sample types. Each dot in figures indicates the prevalence along with the 95% CI associated with each study

FFPE: Formalin-Fixed Paraffin-Embedded

Supplementary Figure 9. Association between HHV-6 and primary brain cancer based on geographical areas. Each dot in figures indicates the prevalence along with the 95% CI associated with each study