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Association between Human Herpesvirus-6 and Primary Brain Tumors: a systematic review and meta-analysis: Supplementary Data

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posted on 12.04.2022, 13:17 authored by Saied Ghorbani, Arash Letafati, Alireza Khatami, Rana farzi, Soha Shabani, Pouya Moradi, Vahid Tambrchi, Hassan Saadati, Saher Papizadeh, Mona Vasei rad, Raheleh Tabatabaei, Saeed Bahadory, Ahmad Tavakoli, Farah Bokharaei-Salim, Seyed Hamidreza Monavari, Maryam Fatemipour, Mahdieh hoseini, Seyed Jalal Kiani

            

Supplementary   Table 1. Search strategy

Supplementary   Table 2. Quality assessment of included studies.


Supplementary   figures 

Supplementary   Figure 1: Funnel plots before (A) and after (B) applying the trim-and-fill   method. The open dots indicate the observed studies, and the closed dots   indicate the missing studies imputed by the trim-and-fill method.

Supplementary Figure 2. The pooled prevalence of   HHV-6 among primary brain cancer patients based on study type. Each dot in   figures indicates the prevalence along with the 95% CI associated with each   study

Supplementary   Figure 3. The pooled prevalence of HHV-6 among primary brain cancer patients   based on Detection method. Each dot in figures indicates the prevalence along   with the 95% CI associated with each study

PCR:   polymerase chain reaction, ELISA: enzyme-linked immunosorbent assay, NGS: next generation sequencing, ISH: in situ   hybridization, IHC: immunohistochemistry

Supplementary   Figure 4. The pooled prevalence of HHV-6 among primary brain cancer patients   based on sample type. Each dot in figures indicates the prevalence along with   the 95% CI associated with each study

FFPE:   Formalin-Fixed Paraffin-Embedded

Supplementary   Figure 5. The pooled prevalence of HHV-6 among primary brain cancer patients   based on geographical area. Each dot in figures indicates the prevalence   along with the 95% CI associated with each study

Supplementary   Figure 6. Overall Association between HHV-6 and primary brain cancer. Each   dot in figures indicates the prevalence along with the 95% CI associated with   each study

Supplementary   Figure 7. Association between HHV-6 and primary brain cancer based on   detection method. Each dot in figures indicates the prevalence along with the   95% CI associated with each study

PCR:   polymerase chain reaction, ISH: in situ hybridization, IHC:   immunohistochemistry

Supplementary   Figure 8. Association between HHV-6 and primary brain cancer based on sample   types. Each dot in figures indicates the prevalence along with the 95% CI   associated with each study

FFPE:   Formalin-Fixed Paraffin-Embedded

Supplementary   Figure 9. Association between HHV-6 and primary brain cancer based on   geographical areas. Each dot in figures indicates the prevalence along with   the 95% CI associated with each study

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