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Association between Human Herpesvirus-6 and Primary Brain Tumors: a systematic review and meta-analysis: Supplementary Data

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posted on 12.04.2022, 13:17 by Saied Ghorbani, Arash Letafati, Alireza Khatami, Rana farzi, Soha Shabani, Pouya Moradi, Vahid Tambrchi, Hassan Saadati, Saher Papizadeh, Mona Vasei rad, Raheleh Tabatabaei, Saeed Bahadory, Ahmad Tavakoli, Farah Bokharaei-Salim, Seyed Hamidreza Monavari, Maryam Fatemipour, Mahdieh hoseini, Seyed Jalal Kiani

            

Supplementary   Table 1. Search strategy

Supplementary   Table 2. Quality assessment of included studies.


Supplementary   figures 

Supplementary   Figure 1: Funnel plots before (A) and after (B) applying the trim-and-fill   method. The open dots indicate the observed studies, and the closed dots   indicate the missing studies imputed by the trim-and-fill method.

Supplementary Figure 2. The pooled prevalence of   HHV-6 among primary brain cancer patients based on study type. Each dot in   figures indicates the prevalence along with the 95% CI associated with each   study

Supplementary   Figure 3. The pooled prevalence of HHV-6 among primary brain cancer patients   based on Detection method. Each dot in figures indicates the prevalence along   with the 95% CI associated with each study

PCR:   polymerase chain reaction, ELISA: enzyme-linked immunosorbent assay, NGS: next generation sequencing, ISH: in situ   hybridization, IHC: immunohistochemistry

Supplementary   Figure 4. The pooled prevalence of HHV-6 among primary brain cancer patients   based on sample type. Each dot in figures indicates the prevalence along with   the 95% CI associated with each study

FFPE:   Formalin-Fixed Paraffin-Embedded

Supplementary   Figure 5. The pooled prevalence of HHV-6 among primary brain cancer patients   based on geographical area. Each dot in figures indicates the prevalence   along with the 95% CI associated with each study

Supplementary   Figure 6. Overall Association between HHV-6 and primary brain cancer. Each   dot in figures indicates the prevalence along with the 95% CI associated with   each study

Supplementary   Figure 7. Association between HHV-6 and primary brain cancer based on   detection method. Each dot in figures indicates the prevalence along with the   95% CI associated with each study

PCR:   polymerase chain reaction, ISH: in situ hybridization, IHC:   immunohistochemistry

Supplementary   Figure 8. Association between HHV-6 and primary brain cancer based on sample   types. Each dot in figures indicates the prevalence along with the 95% CI   associated with each study

FFPE:   Formalin-Fixed Paraffin-Embedded

Supplementary   Figure 9. Association between HHV-6 and primary brain cancer based on   geographical areas. Each dot in figures indicates the prevalence along with   the 95% CI associated with each study

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