%PDF-1.5
%
1 0 obj
<>/OCGs[10 0 R]>>/Pages 3 0 R/Type/Catalog>>
endobj
2 0 obj
<>stream
Adobe Illustrator CS6 (Windows)
2022-03-15T10:49:18+09:00
2022-03-15T10:49:18+08:00
2022-03-15T10:49:18+08:00
88
256
JPEG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1
True
False
494.594444
1426.280556
Millimeters
Arial-ItalicMT
Arial
Italic
Open Type
Version 6.90
False
ariali.ttf
Arial-BoldMT
Arial
Bold
Open Type
Version 6.90
False
arialbd.ttf
ArialMT
Arial
Regular
Open Type
Version 6.90
False
arial.ttf
TimesNewRomanPSMT
Times New Roman
Regular
Open Type
Version 6.96
False
times.ttf
AdobeSongStd-Light
Adobe 宋体 Std
L
Open Type
Version 5.002;PS 5.002;hotconv 1.0.49;makeotf.lib2.0.15106
False
AdobeSongStd-Light.otf
Cyan
Magenta
Yellow
Black
默认色板组
0
application/pdf
Fig.S1
proof:pdf
xmp.did:B4BEFB7607A4EC11B7C5853492DCE2DD
uuid:0fd0fea3-ed5b-4193-86b3-97fdfee6ef78
uuid:7d88ced0-15d5-4dff-95de-a2107c25855d
xmp.iid:B3BEFB7607A4EC11B7C5853492DCE2DD
xmp.did:B3BEFB7607A4EC11B7C5853492DCE2DD
uuid:7d88ced0-15d5-4dff-95de-a2107c25855d
proof:pdf
saved
xmp.iid:B2BEFB7607A4EC11B7C5853492DCE2DD
2022-03-15T10:27:30+08:00
Adobe Illustrator CS6 (Windows)
/
saved
xmp.iid:B4BEFB7607A4EC11B7C5853492DCE2DD
2022-03-15T10:49:15+08:00
Adobe Illustrator CS6 (Windows)
/
Adobe PDF library 10.01
endstream
endobj
3 0 obj
<>
endobj
12 0 obj
<>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/Thumb 177 0 R/TrimBox[0.0 0.0 1402.0 4043.0]/Type/Page>>
endobj
13 0 obj
<>stream
Hԗێ
@+úl!ρaobx7Yo~(K)*rԳ13!"Y~N?߆ ˝aw'wIm qfލݢ}R:
]&KǗt~/7.χ&3g@67PWG>:C#1zxc`~(-0/׀Jǔ[4C$DQRC"D=9bB
KDjviݸxmW@WdΥ !&1kEW1Sot^ou0O AotQPQ2JT60IQB`⛯*_hˏ{Dk(1TVr`107ƀ/JUVAmuv$;4&{u^P٫FRLYF&SE5GFIĠ1a+a"[D8t4kAh)]cV5fc3 z<0kE{
S/?1==H!~6Eϔ0|fSgM΅=;#ϙ__O}94Ĵpwd4y:f4|$x~$7%[|( v9lkS:jh &wHwNkz4A[w$;,h0
hQA[w7C{
Ԩף6QM@S(Q6w7C"tQi_vcqۦ =WѬGQBwP8qbQӣ^V>#ȱ?V4ߛ**Y%g7-Gn}9if
z4,m;Ȃi%R}AbZvWV.p0!ZKn6,5{&vq(Bm9"F
I˹tG:|ڜ
z(uu1<g
;
qGor~3
(uEM:|kdp=h &wHc$l6ƑB:Ўc\Q_*(J:E츣W+A:=ꕋ^?wGITQPtdыT%NzWpdK̴hdz4,-A;CvW2eςe=]{HRuaˡi%Kd=n|I}/ SKuv5a߃@dRQKȤ׃pQ]P9TĆID:0YC%KHE5PBE&!wۄPT[EBEKs]xz2vUxun^^P2b$l
x*s%-և7AhiђjvJ6TIJS%&S%vbi;X|^*
5X:
i[+,%2X!K+=q geĻ("ӆ"i{>h))N1k^کtΠq{I8?|[N$(%^hRxߣ}`1TPZIj0ZC
l̡"jQ4DT#@X>v[[5Z N*˕W7X{?*QXxrZ~$l{*s%-և7e7T4%բ$x!TJc%&S%.Jli;,>/!A 0A 8ǰ{3xcqeci`ItipA2xj2
;!Ͱ>9
Řޔa?
x)RXOy8XK=q/-T3r.Jt&]7 ùga8;?}tyh௯`JTwapoLCL3͚Ü|sfziJ
GGs|=57d!.IX
dKnQiKpwqIɢ
L]uL%L Oz[ЅDŽ(JXC 9&lS:&HWE*Koo;m ibf0jv
.21q1ET[`z?]$ځqL5[IǬZc9l
vڮH{A7c+at4U-jU:[HÖmbg_ƙX&uF[
ZiIsDÙ;˴X/UjzCx!6 =$
7I(ar41$a"6?[`ԅ[c!m~v*8t19&HCNnSnSD c!uVc>vj`%L&]TIتá^^V\RaԬ`&\dx1`3i
{,pTU"3㙬Y+&XUdXL9p:Fx+Vaoz@f1phI^ϔVi[VPeYN#ñ+0x}x|OqٺOً(^1&~1_<9ʧ|00G2"-#Ȥ%SnHi;5JDt8Zͬ3_erG~ez_#Y0b;?8cǒ) |}No$,
g},CÖV!G`s=ϟCMۦqΏ($H`)6nR0T1? D!EK)`⟡̗*wv#N:wc(<NTYCIDŽ@pLL`T=1Z/UI_AU>#ߨyX
qR)`t
,{B+p7?뮟
g)q.=;BjϦ*`م3;=@(rնjGZ6lɾض{%Bk8-" DE j"wv?K/%ܾ{^0O:q_jO:ƞt?
4J*:Fs})O<[0 Lj@8_(c' %a0+eMTrv:W$riZ
L8&*1d|˧Sʆj<9k~:Ё;Dnzx:-dj$;:a]=l&-"N'AY7?lxx CZb~ZŐK1:Ra*?J7?,X+d EZ-ǯ;cL -J0B
WWdḔ?HZ:wW^MV(AODS#@RX+Ňj>@6ɍ]l")8BDG{p $6z-Ć*>T@76)]l)X
M"?oc2@%DlnQEk~FPc^J>TQоM7154CsaMMqG\ZxjPEA6ϱ eUlC=%l61TDDBPɇ*j1CuY@lsbb>&e41yB*H12Ͱ NHVRUb{aoc Xa"
U|>n&T/`F_{LJz>4@6SlBN";ɇЍM!mB&p $6zWS^&&^6T/́J|*(oeo9PZDhPyTS
(h&n e5=956|yjTDu|M67ۄ"2}O??`1vR8,ёZ4Dđ
}Xp2Ix絟Gw=I:O?iZݳq>Wy)FyOO>:BV)QL> qz8c~+B4[AJ9۸8G٦
63q[4:6L1]n֏B"!>ѹ!YwL;$I.^|+,dbr//~)JɺcYp(&!B^}V;6>/emYqδˊW>D"*\9Vz#J8bO2H|+v
-4/~P1N
,#\ աz(ϖ=oӒ\Yuym