Supported by the Biomedical Research Networking Center (CIBER), Spain. CIBER is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions, and the Instituto de Salud Carlos III (RD16/0006/0012; RD16/0011/0022), with the support of the European Regional Development Fund (ERDF). This work was funded by the CERCA Program and by the Commission for Universities and Research of the Department of Innovation, Universities and Enterprise of the Generalitat de Catalunya (2017 SGR 1079). This work was developed in the context of the AdvanceCat project (COMRDI15-1-0013) with the support of ACCI´O (Catalonia Trade and Investment; Generalitat de Catalunya) under the Catalonian ERDF operational program, 2014–2020. This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the projects MINDS (Proyectos I + D Excelencia + FEDER): TEC2015-70104-P-P and BIOBOT (Programa Explora Ciencia/Tecnolog´ıa): TEC2015-72718-EXP, as well as the Spanish Ministry of Science and Education (PID2019-104293GBI00), the Spanish Ministry of Science and Innovation (Proyectos de I + D + I Programacio´ n Conjunta Internacional, EuroNanoMed 2019 (PCI2019-111825-2) and the Consejer´ıa de Salud, Junta de Andaluc´ıa (UMA18-FEDERJA-007; UMA18-FEDERJA-133) and Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia (PY20 00384). The authors further acknowledge funds from the INTERREG V cooperation program for Spain–Portugal (POCTEP) 2014–2020 project (0245 IBEROS 1 E). I Casanellas acknowledges support from MINECO through the Subsidies for Predoctoral Contracts for the Training of Doctors open call, cofunded by the European Social Fund (2016), grant number: BES-2016-076682. C Rodr´ıguez- Pereira acknowledges support from i-PFIS Doctoral Program (IFI15/00151) funded by ISCIII.