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supplemental figures: Multiomics, virtual reality and artificial intelligence in heart failure.docx

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posted on 19.05.2021, 12:16 by Patrick A. Gladding, Suzanne Loader, Kevin Smith, Erica ZarateErica Zarate, Saras GreenSaras Green, Silas Villas-BoasSilas Villas-Boas, Phillip ShepherdPhillip Shepherd, Purvi KakadiyaPurvi Kakadiya, William HewittWilliam Hewitt, Eric ThorstensenEric Thorstensen, Christine KevenChristine Keven, Margaret CoeMargaret Coe, Bahareh Nakisa, Tan Vuong, Mohammad Naim Rastgoo, Mia Jüllig, Vito Starc, Todd Schlegel

Supplemental Figure 1 - Serial advanced ECG (A-ECG) results as summarized by 2D and 3D Linear Discriminant Analysis plots for an example patient, a 39-year old Samoan woman with MELAS mtDNA m.3243A > G DCM treated with mitoquinone, zinc, riboflavin, thiamine and conventional heart failure medical therapy. Points (1) to (5) indicate A-ECG results from 5 distinct (serial) ECGs performed over one week, with point (4) the A-ECG result during a worsened clinical condition after metoprolol was titrated to 190mg once daily. Probability of the presence of a given disease state is grossly demonstrated by the relative proximity of the patient's given number to a given disease state (larger circles), the latter being derived from a pre-existing database of A-ECG information from thousands of earlier patients with known, imaging-proven cardiac health or disease. Note however that because this is a 2D representation of a 3D space (right), a patient’s number may sometimes have the appearance of proximity to a disease circle in the x and y planes shown, but in the z plane the distance may actually be closer to some other sphere. CAD/CMVD = Coronary Artery Disease and/or Coronary Microvascular Disease Population; LVH/LVE = Left Ventricular Hypertrophy or Enlargement population; HOCM/HCM = Hypertrophic Cardiomyopathy population; NICM = Non-Ischemic Cardiomyopathy population; ICM = Ischemic Cardiomyopathy population; and LQTS = Long QT Syndrome (LQTS) population, respectively.

Supplemental Figure 2 - ECGs (1) above and (4) below.

Funding

Health Research Council of New Zealand Explorer Grant 16/680

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