imt-2021-0135: Supplementary Material: Chemotherapy or chemo-immunotherapy as first-line treatment for extensive-stage small-cell lung cancer- a meta-analysis
figureposted on 15.07.2021, 11:28 by Figshare Future Science GroupFigshare Future Science Group, Ching-Yi Chen, Wang-Chun Chen, Chao-Ming Hung, Yu-Feng Wei
Supplementary Figure S5: Forrest plot of serious immune-related adverse events comparing chemo-immunotherapy and chemotherapy alone
Methods/Results: Seven randomized controlled trials with a total of 2,862 patients were analyzed. Compared with chemotherapy alone, chemo-immunotherapy provided a better progression-free survial (PFS) with a hazard ratio (HR) of 0.81; P<0.00001, and overall survival (OS) (HR, 0.82; P<0.0001). However, the incidence of treatment related adverse effects (TRAEs) was significantly increased. Subgroup analyses showed that a good performance status, cisplatin-based chemotherapy, without brain metastases, and non-Asian populations were associated with greater benefits in OS from chemo-immunotherapy.
Conclusion: Chemo-immunotherapy demonstrated better PFS and OS compared to chemotherapy alone as first-line treatment in ES-SCLC, but additional TRAEs should be closely monitored.