Aim: To evaluate the performance of urinary fibrinogen
β-chain (FBC), and the association of FBC and urinary tyrosine-phosphorylated
proteins (UPY) as diagnostic biomarkers. Methods: 164 subjects were included.
Results: FBC and UPY levels have shown a significant difference between BCa
patients vs controls and discriminate between low-grade and high-grade cancers.
The diagnostic accuracy was 0.84 for FBC and 0.87 for UPY. The combination of
FBC and UPY improved the accuracy (0.91). The addition of clinical variables
(age, gender, and smoking habit) to FBC and UPY significantly improved the
accuracy (AUC 0.99). Conclusions: This model reached the highest sensitivity
and a good specificity and can be proposed as biomarker for BCa diagnosis.