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The placenta epigenome–brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment. Supplementary figures and tables

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posted on 2022-09-08, 07:29 authored by Rebecca C Fry, Thomas Michael O'Shea, Karl CK Kuban, Robert M. Joseph, Hudson P. Santos, Jacqueline Bangma, Lisa Smeester, Noemi Gavino-Lopez, Julia E. Rager, Lauren A. Eaves, Anastasia N. Freedman

Supplemental Table 1. T-test results comparing differences mean count values in the differentially expressed genes between participants with any chorioamnionitis or inflammation (n= 173), and participants without any chorioamnionitis or inflammation (n= 189). Significance defined at p<0.05. Data does not include missing values.


Supplementary Figure 1.  Three surrogate variables captured variability across the principal components of the mRNA and miRNA data.


Supplementary Figure 2.  A causal directed acyclic graph approach was used to identify a minimal sufficient adjustment set of covariates to be included in the statistical model.


Supplementary Figure 3.  The sex-stratified analysis demonstrated 0 significant differentially expressed genes among female-derived placentas and 37 genes that were differentially expressed among male-derived placentas.

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