Synthetic Benzofuran-linked Chalcones with Dual Actions: A Potential Therapeutic Approach to Manage Diabetes Mellitus - Supplementary Material

  

Figure-S1: Comparison of structures and α-amylase inhibitory activity of molecules 20-26.

  

Figure-S2: Comparison of structures and α-amylase inhibitory activity of analogs 27-33

  

Figure-S3: Graph of compound 2; Lineweaver-Burk plot of the reciprocal of rate of reaction (velocities) vs reciprocal of the substrate (starch) in different inhibitor concentrations with error bars.

  

Figure-S4: Graph of compound 2; Dixon plot of reciprocal of rate of reaction (velocities) vs different concentrations of inhibitor with error bars.

  

Table-S1: Kinetic studies data of selected compounds for α-amylase inhibition

  

Figure-S5: Interaction Profile of potent compounds against the α-amylase enzyme. a-d for compounds 2, 4, 7, and 9, respectively, double-sided arrow and dashes lines indicate pi-stacking and hydrogen interaction.

  

Table-S2: Interaction data for compounds 1-33.

  

Figure-S6: Graphical representation of variation in DPPH and ABTS radical scavenging activity of compounds 1-33