Synergistic chemo-photothermal and ferroptosis therapy of polydopamine nanoparticles for esophageal cancer - Supplementary Figures nnm-2022-0064

Synergistic treatment with multiple therapies has been shown to be a promising strategy for cancer treatment. Here, the authors designed Fe3O4@PDA-HCPT NPs composed of Fe3O4, polydopamine and the chemotherapy drug 10-hydroxycamptothecin. The authors achieved synergistic antitumor treatment with chemo-photothermal and ferroptosis therapy guided by T2-weighted MRI. In vitro and in vivo experiments showed that Fe3O4@PDA-HCPT NPs exhibited significant tumor inhibition and excellent diagnostic properties, which supports the development of relevant synergistic tumor therapies.