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Synergistic chemo-photothermal and ferroptosis therapy of polydopamine nanoparticles for esophageal cancer - Supplementary Figures nnm-2022-0064

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posted on 2022-09-14, 08:31 authored by Yukun Chen, Mingliang Su, Lijun Jia, Zhanxia Zhang

Synergistic treatment with multiple therapies has been shown to be a promising strategy for cancer treatment. Here, the authors designed Fe3O4@PDA-HCPT NPs composed of Fe3O4, polydopamine and the chemotherapy drug 10-hydroxycamptothecin. The authors achieved synergistic antitumor treatment with chemo-photothermal and ferroptosis therapy guided by T2-weighted MRI. In vitro and in vivo experiments showed that Fe3O4@PDA-HCPT NPs exhibited significant tumor inhibition and excellent diagnostic properties, which supports the development of relevant synergistic tumor therapies.

Funding

National Natural Science Foundation of China, (Grant / Award Number: '81625018','81820108022','82003297')

Natural Science Foundation of Shanghai, (Grant / Award Number: '20ZR1459100')

Program of Shanghai Academic Research Leader , (Grant / Award Number: '18XD1403800')

Biomedical Science and Technology Support Project of Shanghai, (Grant / Award Number: '22S11900800')

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