Supplementary data.docx (3.37 MB)

Supplementary material. Synthesis and Characterization of Potent RIPK3 Inhibitors Based on a Tricyclic Scaffold

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posted on 2022-02-15, 18:24 authored by Xiaohu Zhang, Shuwei Wu, Qing Yang, Yuting JiYuting Ji, Sheng Tian, Haikuo Ma, Shujing Du, Haohao Lu, Sudan He

Molecular docking study

Chemistry

Preliminary in vitro safety and DMPK test

Kinase binding (Kd) assay

NMR spectra

Funding

National Natural Science Foundation of China 81973161, 81773561, 21502133, 31671436, 31830051

Special Research Fund for Central Universities, Peking Union Medical College 2021-PT180-001

the CAMS Innovation Fund for Medical Sciences 2021-I2M-1-041, 2021-I2M-1-047 and 2021-I2M-1-061

the Jiangsu Key Laboratory of Neuropsychiatric Diseases BM2013003

the Priority Academic Program Development of the Jiangsu Higher Education Institutes

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Synthesis and Characterization of Potent RIPK3 Inhibitors Based on a Tricyclic Scaffold

Future Medicinal Chemistry

Keywords

necroptosis RIPK3 Kinase structure optimization SAR Biochemistry and Cell Biology not elsewhere classified

Licence

CC BY 4.0