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Supplementary data.docx (3.37 MB)

Supplementary material. Synthesis and Characterization of Potent RIPK3 Inhibitors Based on a Tricyclic Scaffold

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posted on 2022-02-15, 18:24 authored by Xiaohu Zhang, Shuwei Wu, Qing Yang, Yuting Ji, Sheng Tian, Haikuo Ma, Shujing Du, Haohao Lu, Sudan He
Molecular docking study
Preliminary in vitro safety and DMPK test
Kinase binding (Kd) assay
NMR spectra


National Natural Science Foundation of China 81973161, 81773561, 21502133, 31671436, 31830051

Special Research Fund for Central Universities, Peking Union Medical College 2021-PT180-001

the CAMS Innovation Fund for Medical Sciences 2021-I2M-1-041, 2021-I2M-1-047 and 2021-I2M-1-061

the Jiangsu Key Laboratory of Neuropsychiatric Diseases BM2013003

the Priority Academic Program Development of the Jiangsu Higher Education Institutes