Supplementary figures - Gold nanoblackbodies mediated plasmonic photothermal cancer therapy for melanoma nnm-2022-0052

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posted on 2022-09-22, 15:56 authored by Divya Khurana, Rajesh Dudi, Sanket K Shukla, Deepika Singh, Dilip Manikrao Mondhe, Sanjeev Soni

Aim: Gold nanoblackbodies (AuNBs)-mediated plasmonic photothermal cancer therapy was investigated

through melanoma-bearing mice. Materials & methods: Polydopamine-coated Au nanoclusters were

synthesized, termed AuNBs and PEGylated AuNBs (AuNBs-PEG). The photothermal response of AuNBs-

PEG was evaluated upon low-intensity broadband near-infrared irradiation (785/62 nm; 0.9 Wcm-2),

and cytotoxicity was assessed on B16-F10 cells. Further, the therapeutic potential of intravenously

administered AuNBs-PEG was evaluated on B16-F10 melanoma in C57BL/6 mice. Results: AuNBs-PEG

showed an excellent photothermal response (photothermal conversion efficiency of 60.3%), robust

photothermal stability and no cytotoxicity. For AuNB-mediated plasmonic photothermal therapy, an

average temperature of 63◦C was attained within 5 min of irradiation, and tumors were eradicated.

Conclusion: AuNBs-PEG are promising photothermal agents for treating melanoma through low-intensity

broadband near-infrared irradiation.

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