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Supplementary figure S6. Electrochemical methods for probing DNA damage mechanisms and designing cisplatin-based combination chemotherapy

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posted on 20.03.2019 by Zhi Li, Yael Zilberman, Qing-Bin Lu, Xiaowu (Shirley) Tang
Figure S6. The effect of PEG-rGO on DNA damage. CV curves of 500 µM dGMP mixed with 500 µM cisplatin and (a) 0.15 mg/ml, (b) 0.75 mg/ml PEG-rGO at various time points (scan rate: 20 mV/s). (c) Oxidation peak values. (d) Reaction kinetics study of 500 µM dGMP mixed with 500 µM cisplatin, 500 µM Cisplatin+ 0.15 mg/ml PEG-rGO and 500 µM CDDP+ 0.75 mg/ml PEG-rGO over time.

Figure S6 shows that the reaction rate remained unchanged with the introduction of PEG-rGO. Therefore the conclusion is that PEG-rGO doesn’t promote dGMP damage.

Funding

This work was supported by an operating grant to QBL from the Canadian Institutes of Health Research (CIHR) and Discovery grants to QBL and ST from the Natural Science and Engineering Research Council of Canada (NSERC).

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