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Supplementary_figure: Prognostic implications of PD-L1 expression in patients with angiosarcoma

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posted on 21.05.2021, 10:50 by Jii Bum Lee, Beung-Chul Ahn, Seung Hyun Kim, Young Han Lee, Jung Woo Han, Min Kyung Jeon, Soo Hee Kim, Hyo Song Kim
Background: There are limited data on the feasibility of programmed death ligand-1 (PD-L1) expression as a prognostic biomarker in metastatic angiosarcoma. Materials & Methods: We retrospectively collected and analyzed the data on PD-L1 expression in 70 angiosarcoma patients who were diagnosed at our center between 2005 and 2019. Results: Thirteen (19%) patients had PD-L1 expression. Metastatic angiosarcoma patients who were PD-L1-negative (n=24) showed longer median progression-free survival (4.9 vs. 1.6 months; p=0.04) and median overall survival (OS; 10.9 vs. 5.4 months; p=0.01) than those who were PD-L1-positive (n=4). PD-L1 status proved to be a significant factor for OS. Conclusions: Metastatic angiosarcoma patients with PD-L1 expression showed shorter survival. PD-L1 status is an independent prognostic factor for OS in metastatic angiosarcoma patients.


Financial disclosure: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2018R1A2B6003707, Hyo Song Kim) and a Severance Hospital Research fund for clinical excellence (SHRC, C-2019-0015, Hyo Song Kim).