Supplementary data: The Diagnostic Value of Soluble T-Cell Immunoglobulin and Mucin Domain-3 in Oral Squamous Cell Carcinoma

Supplementary Figure 1. The Diagnostic Value of Soluble T-Cell Immunoglobulin and Mucin Domain-3 in Oral Squamous Cell Carcinoma

ROC analyses of soluble TIM-3 (A), SCCAg (B), and SCCAg combined soluble TIM-3 (C) to distinguish stage I patients (Red) from healthy individuals and stage II patients (Green) from healthy individuals.

Supplementary Table 1. The Diagnostic Value of Soluble T-Cell Immunoglobulin and Mucin Domain-3 in Oral Squamous Cell Carcinoma

SCCAg and sTIM-3 in the diagnosis of Stage I patients and Stage II patients

Abstract

Objective: To evaluate the soluble T-cell immunoglobulin and mucin domain-3 (sTIM-3) expression levels in oral squamous cell carcinoma (OSCC) and determine its clinical diagnostic potential.

Methods: The sTIM-3 and squamous cell carcinoma antigen (SCCAg) levels of 199 OSCC patients and 107 healthy individuals were assessed both using an enzyme-linked immunosorbent assay and their individual and combined efficiency rates were compared.

Results: The results showed higher sTIM-3 and SCCAg levels in the OSCC patients and better combined diagnostic potential for these markers than their individual assessments as well as positive correlation of sTIM-3 levels with clinicopathological factors.

Conclusions: sTIM-3 is a potentially novel and readily accessible OSCC biomarker, which in combination with SCCAg expression level might better diagnose the OSCC patients.