Supplementary Tables. Economic analysis of the use of video laryngoscopy versus direct laryngoscopy in the surgical setting.
Supplementary Figure S1. UCSC Genome Browser view of the NAMPT promoter region with the location of the functional SNPs rs59744560 and rs61330082, histone modifications and several ENCODE data. The region shows an enrichment for the active histone mark H3K27ac, the H3K4me3 associated with active promoters, and it has a promoter element identified by GeneHancer (GH07J106281).
Supplementary Figure S2. Linkage disequilibrium among SNPs in the NAMPT promoter region for the East Asian (CHB+JPT) population. The numbers below the rs IDs correspond to the number of SNPs found for this population. Values for pairwise D´ are presented in each box; those without values refer to D´=1. Color scheme: bright red, D′ = 1 and logarithm of odds (LOD) ≥ 2.
We examined the relationships between visfatin/NAMPT
and nitrite concentrations (a marker of NO formation) or sFlt-1 levels in 205
patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive
therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite
concentrations in PE and 206 healthy pregnant women.
visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite
concentrations using an ozone-based chemiluminescence assay. Results: In
nonresponsive PE patients, visfatin/NAMPT levels were inversely related to
nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP
rs1319501 affected nitrite concentrations in nonresponsive PE patients and was
tightly linked with NAMPT functional SNPs in Europeans. Conclusions: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO
formation, sFlt-1 levels, and antihypertensive therapy response in PE.