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Supplementary Material – The effect of AS1411 surface density on the tumor targeting properties of PEGylated silver nanotriangles

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posted on 21.01.2022, 12:07 authored by Figshare Future Science GroupFigshare Future Science Group, Yuyu Cao, Huiquan Yang, Dongdong Li, Fan Li, Jing Ma, Peidang Liu

Figure 1. XRD pattern of AgNTs.

XRD: X-ray diffraction; AgNTs: silver nanotriangles.

Figure 2. FTIR spectra of Chitosan, AgNTs, PNTs, 0.5-ANTs, 1-ANTs, 5-ANTs, 10-ANTs and 15-ANTs.

FTIR: Fourier transform infrared. AgNTs: silver nanotriangles; PNTs: PEGylated silver nanotriangles; 0.5-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 0.5%; 1-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 1%; 5-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 5%; 10-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 10%; 15-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 15%.

Figure 3. Cellular uptake of PNTs and ANTs with different AS1411 densities. Dark-field microscopy images of MDA-MB-231 cells treated with PNTs, 0.5-ANTs, 1-ANTs, 5-ANTs, 10-ANTs or 15-ANTs (2 μg/mL) for 6, 12, 24 or 48 h.

PNTs: PEGylated silver nanotriangles; 0.5-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 0.5%; 1-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 1%; 5-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 5%; 10-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 10%; 15-ANTs: PEGylated silver nanotriangles modified with AS1411 density of 15%.

Funding

National Natural Science Foundation of China (81771980 and 81571805)

National Key Basic Research Program of China (973 Program; 2013CB933904).

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