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Supplementary Figures S1 and S2. Computational drug repositioning for ischemic stroke: Neuroprotective drug discovery

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posted on 17.06.2021, 13:51 by Xiujie Chen, Yunong Li, Jingbo Yang, Yan Zhang, Qingkang Meng, Andreas Bender
Supplementary Figure S1. Brain-protective gene-domain-substructure-drug network. It contains 22 genes, 24 domains, 480 substructures, and 2297 drugs. The red node represents the gene, the blue node represents the drug, and the green node represents the domain-substructure.

Supplementary Figure S2. Elbow method (clustering). This method is used to find the appropriate number of clusters in the brain-protective gene-domain-substructure-drug dataset of K-means clustering. According the “elbow criterion”, the number of clusters chosen should be 8. The "elbow" is indicated by the red dot.


China Postdoctoral Science Foundation Grant No. 2019M661302

National Natural Science Foundation of China Grant No. 61671191 Grant No. 61971166