new Supplementary Fig. S4.tif (2.37 MB)

Supplementary Figure 4. Silver nanoparticles induce apoptosis via NOX4-derived mitochondrial ROS and ER stress in colorectal cancer cells

figure

posted on 2021-05-20, 09:27 authored by Juan-Hua Quan, Fei Fei Gao, Jia-Qi Chu, Guang-Ho Cha, Jae-Min Yuk, Weiyun Wu, Young-Ha Lee

Supplementary Figure 4. AgNPs induced CHOP expression in HCT116 cells dose dependently. Representative images obtained by confocal fluorescence microscopy with CHOP antibody staining. Nuclei were counter-stained with DAPI. AgNPs significantly upregulated nuclear and cytosol CHOP protein expression in HCT116 cells in a dose-dependent manner.

Funding

This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2019R1A2C1088346) at Chungnam National University, and the National Natural Science Foundation of China (81971389 and 81771612), the Characteristic Innovation Projects of Guangdong Universities (2018KTSCX079, 2018KTSCX081) and the Guangdong Basic and Applied Basic Research Foundation (2019A1515011888 and 2019A1515011715).

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Cancer cell biology

Keywords

Silver nanoparticles Colorectal cancer Reactive oxygen species Apoptosis NOX4 ER stress Xenograft nude mice Cancer Cell Biology

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CC BY-NC-ND 4.0

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