Supplementary Figure 3. Silver nanoparticles induce apoptosis via NOX4-derived mitochondrial ROS and ER stress in colorectal cancer cells
figureposted on 2021-05-20, 09:27 authored by Juan-Hua Quan, Fei Fei Gao, Jia-Qi Chu, Guang-Ho Cha, Jae-Min Yuk, Weiyun Wu, Young-Ha Lee
Supplementary Figure 3. AgNPs induced PARP cleavage through mitochondrial ROS in HCT116 cells. HCT116 cells were pretreated with or without 0.5 μM DPI for 4 h and incubated with 5 μg/ml AgNPs for 24 h. Representative images obtained by confocal fluorescence microscopy stained with cleaved PARP antibody. Cleaved PARP-positive cells were observed following the AgNP treatment while cleaved PARP-positive cells were apparently decreased in cells pretreated with DPI.