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Supplementary Figure 2. Statin therapy is associated with epigenetic modifications in individuals with type 2 diabetes

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posted on 05.05.2021, 07:54 by Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón, Charlotte Ling

ABSTRACT

Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associate with epigenetics in type 2 diabetes (T2D) patients. Material & Methods: DNA methylation was analysed in blood from newly diagnosed T2D patients from ANDIS and in a replication cohort (ANDiU). Results: 79 sites were differentially methylated between cases on statins and controls (FDR<5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685), and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.

Funding

Novo nordisk foundation, Swedish Research Council, Region Skåne (ALF), H2020-Marie Skłodowska-Curie grant agreement No 706081 (EpiHope), Hjärt Lund fonden, Exodiab, Swedish Foundation for Strategic Research for IRC15-0067, Swedish Diabetes Foundation, ERC-Co grant (PAINTBOX no 725840).

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