new Supplementary Fig. S1.tif (2.29 MB)
Supplementary Figure 1. Silver nanoparticles induce apoptosis via NOX4-derived mitochondrial ROS and ER stress in colorectal cancer cells
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posted on 2021-05-20, 09:27 authored by Juan-Hua Quan, Fei Fei Gao, Jia-Qi Chu, Guang-Ho Cha, Jae-Min Yuk, Weiyun Wu, Young-Ha Lee
Supplementary Figure 1. AgNPs induced morphological changes in HCT116 cells dose- and time-dependently. HCT116 cells were treated with various concentrations of AgNPs for 24 h or 5 μg/mL AgNPs for the indicated times. (A, B) HCT116 cells were fixed and probed against α-tubulin (red). The cells were counterstained with DAPI (blue) and visualized by confocal microscopy. Untreated control HCT116 cells displayed a well-developed array of hair-like microtubule networks of slim fibrous microtubules wrapped around the cell nucleus. In contrast, cells treated with AgNPs showed a tubulin staining pattern that was diffuse and disorganized. |