Supplementary Figure 1: Effects of lyoprotectants on long-term stability and transfection efficacy of lyophilized poly(lactide-co-glycolide)-graftpolyethylenimine/ plasmid DNA polyplexes.tiff

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posted on 2021-05-28, 09:00 authored by Joshua Woo, Jeoung Soo Lee

Supplementary Figure 1. Characterization of Poly(lactic acid-co-glycolic acid)-graft-polyethylenimine (PgP) by ¹H-NMR (300 MHz, Bruker) using D₂O as a solvent: δ=1.4~1.6 (d, 3H, PLGA -CH₃), δ=4.3 (q, 1H, PLGA-CH), δ=3.9 (s, 2H, PLGA –CH₂), δ=2.4~3.5 (m, PEI backbone -CH₂)

Funding

This research was supported by the National Institute of General Medical Sciences (NIGMS) of the NIH under award number 5P20GM103444-07 and partly supported by the National Institute of Neurological Disorders and Strokes (NINDS) of the NIH under Grant number 5R01 NS111037-02. This research was also supported by the South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SCBioCRAFT).

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Medical genetics (excl. cancer genetics)

Keywords

Gene delivery cationic amphiphilic polymer polymeric micelle nanoparticles lyophilization lyoprotectants long-term shelf life Medical Genetics (excl. Cancer Genetics)

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CC BY-NC-ND 4.0

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