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Supplementary Fig 7 - Collagen fibrous scaffolds for sustained delivery of growth factors for meniscal tissue engineering

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posted on 07.01.2022, 10:02 by Jihye Baek, Kwang Il Lee, Ho Jong Ra, Martin K Lotz, Darryl D D’Lima

Supplementary Figure 7. Representative histologic images of ex vivo repair: H&E, Safranin O/fast green, collagen type I immunostaining, PDGFRb immunostaining, and DAPI. (Note this is the 10x mag. view of histologic slides in Figure 7) Surgically created tears implanted with (a) Control = unconjugated collagen scaffolds, (b) HCOL = heparin conjugated collagen scaffolds, (c) PDGF-BB, (d) TGFb1, or (e) CTGF coated on heparin conjugated collagen scaffolds. (Mag. 10x; scale bar: 200 µm). All constructs were cultured for 3 weeks and then processed for histology.


This work was supported by the National Institutes of Health [P01 AG007996. 2016]; the Shaffer Family Foundation; and by Donald and Darlene Shiley.