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Simultaneous multicolor imaging of lymphnode chains using hydroporphyrin-doped near-infrared-emitting polymer dots  - supplementary figures

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posted on 2023-05-31, 09:57 authored by Takuya Kato, Connor Riahin, Aki Furusawa, Hiroshi Fukushima, Hiroaki Wakiyama, Shuhei Okuyama, Seiichiro Takao, Peter L Choyke, Marcin Ptaszek, Zeev Rosenzweig, Hisataka Kobayashi

Aim: Evaluation of lymphatic drainage can be challenging to differentiate between separate drainage

basins because only one ‘color’ is typically employed in sentinel node studies. This study aimed to test the

feasibility of multicolor in vivo lymphangiography using newly developed organic polymer dots. Materials

& methods: Biocompatible, purely organic, hydroporphyrin-doped near-infrared-emitting polymer dots

were developed and evaluated for in vivo multicolor imaging in mouse lymph nodes. Results & conclusion:

The authors demonstrated successful multicolor in vivo fluorescence lymphangiography using polymer

dots, each tuned to a different emission spectrum. This allows minimally invasive visualization of at least

four separate lymphatic drainage basins using fluorescent nanoparticles, which have the potential for

clinical translation.

Funding

U.S. Department of Energy, (Grant / Award Number: 'DE-SC0020346')

National Institute of General Medical Sciences, (Grant / Award Number: 'NIH/NIGMS T32 GM066706')

National Cancer Institute, (Grant / Award Number: 'ZIA BC 011513')

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