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Sequence analysis of Epstein–Barr virus BALF2 gene in associated tumors and healthy individuals from southern and northern China: Supplementary figure

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posted on 2022-07-07, 15:09 authored by Cai-xia Yu, Wen Liu, Meng-he Zhao, Hua Xiao, Yun Wang, Bing Luo

Aim: The purpose of this study is to investigate the polymorphism and distribution characteristics of

BALF2 gene in Epstein–Barr virus (EBV)-associated tumors (gastric cancer, nasopharyngeal carcinoma and

lymphoma). Materials & methods: DNA sequences of 349 EBV-related samples were analyzed by nested

PCR combined with DNA sequencing. Results: According to the phylogenetic tree, BALF2 was divided into

six genotypes (BALF2-A–F). Statistically, the incidence of BALF2-E in nasopharyngeal carcinoma was higher

than that in healthy people, and the incidence of BALF2-E in nasopharyngeal carcinoma in South China

was higher than that in North China (p = 0.001). Conclusion: BALF2 variants in EBV-associated


This work was supported by the Shandong Provincial Natural Science Foundation (ZR2020MH302).


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