FSOA-2019-0023 Graphical abstract.pdf (110.6 kB)

Predictive value and clinical significance of increased SSAT-1 activity in healthy adults: graphical abstract

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posted on 01.07.2019 by Paramjit S Tappia, Andrew W Maksymiuk, Daniel S Sitar, Parveen S Akhtar, Nazrina Khatun, Rahnuma Parveen, Rashiduzzaman Ahmed, Rashid Bux Ahmed, Brian Cheng, Gina Huang, Horacio Bach, Brett Hiebert, Bram Ramjiawan
Graphical Abstract.
Aim: Spermidine/spermine N1-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). Although SSAT-1 is activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration. This study was undertaken to examine the outlier group. Results: In some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. Clinical and radiographic assessments revealed underlying abnormalities in other cases that could represent pre-malignant conditions. Hematology tests revealed elevations in white blood cells and platelets which are markers of inflammation. Conclusion: High urine concentration of AA could be used as a simple and useful test for screening of cancer in high risk populations.

Funding

None of the authors has conflict of interest to disclose. However, RB Ahmed is the President and CEO and B Cheng is the acting CTO of BioMark Diagnostics Inc. A Maksymiuk, DS Sitar, H Bach, PS Tappia and B Ramjiawan are minor shareholders of BioMark Diagnostics Inc. This study was supported, in part, by Biomark Diagnostics Inc. (Richmond, BC, Canada) and the Maunders-McNeil Foundation (Edmonton, AB, Canada). LC/MS/MS analysis was conducted by Biopharmaceutical Research Inc. (Vancouver, BC, Canada). Infrastructural support was provided by the St Boniface Hospital Foundation and the University of Manitoba

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