# PI3K/AKT/mTOR inhibitors plus fulvestrant for postmenopausal，advanced or metastatic HR +, HER2 - breast cancer. - Supplementary figures.docx

Supplementary Fig 1: Assessment of risk of bias in included studies.

Supplementary Fig 2: Funnel plot of comparison: the total population’ progression-free survive (PFS).

Supplementary Fig 3: Funnel plot of comparison: the PI3K pathway-activated’ progression-free survive (PFS).

Supplementary Fig 4: Funnel plot of comparison: the total population’ overall survive (OS).

Supplementary Fig 5: Funnel plot of comparison: the PI3K pathway-activated’ overall survive (OS).

Supplementary Fig 6: Forest plot of comparison: the total population’ objective response rate (ORR).

Supplementary Fig 7: Forest plot of comparison: the total population’ clinical benefit rate (CBR).

Supplementary Fig 8: Funnel plot of comparison: the total population’ objective response rate (ORR).

Supplementary Fig 9: Funnel plot of comparison: the total population’ clinical benefit rate (CBR).

Supplementary Fig 10: Forest plot of comparison: the total population’ grade 3-5 adverse events.

Supplementary Fig 11: Funnel plot of comparison: the total population’ grade 3-5 adverse events.

Supplementary Fig 12: Forest plot of comparison: the total population’ hyperglycemia.

Supplementary Fig 13: Funnel plot of comparison: the total population’ hyperglycemia

Supplementary Fig 14: Forest plot of comparison: the total population’ elevated ALT.

Supplementary Fig 15: Funnel plot of comparison: the total population’ elevated ALT.

Supplementary Fig 16: Forest plot of comparison: the total population’ elevated AST.

Supplementary Fig 17: Funnel plot of comparison: the total population’ elevated AST.

Supplementary Fig 18: Forest plot of comparison: the total population’ rash.

Supplementary Fig 19: Funnel plot of comparison: the total population’ rash.

Supplementary Fig 20: Forest plot of comparison: the total population’ diarrhoea.

Supplementary Fig 21: Funnel plot of comparison: the total population’ diarrhoea.

Supplementary Fig 22: Forest plot of comparison: the total population’ stomatitis

Supplementary Fig 23: Funnel plot of comparison: the total population’ stomatitis.