PDE4 inhibitors for disease therapy: advances and future perspective

PDE4 inhibitors for disease therapy: advances and future perspective.   

Supplementary Figure 1. Chemical structure of Compound 57-76. 

Supplementary Figure 2. (A) Chemical structure of compounds 77-88.(B) Crystal structure of AChE (PDB:4EY7) combined with PDB4D (PDB:3G4L).(C) Surface appearance of PDE4D catalytic bag (PDE4D- Compound 84).