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PDE4 inhibitors for disease therapy: advances and future perspective

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posted on 2023-07-20, 08:38 authored by Boachan Du, Min Luo, Changyu Ren, Jifa Zhang

PDE4 inhibitors for disease therapy: advances and future perspective.   

Supplementary Figure 1. Chemical structure of Compound 57-76. 

Supplementary Figure 2. (A) Chemical structure of compounds 77-88.(B) Crystal structure of AChE (PDB:4EY7) combined with PDB4D (PDB:3G4L).(C) Surface appearance of PDE4D catalytic bag (PDE4D- Compound 84).


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