Nanotherapeutic potential of antibacterial folic acid-functionalized nanoceria for wound-healing applications - Supplementary figures
Aim: The functionalization and characterization of antibacterial nanoceria with folic acid (FA) and
elucidation of their in vivo wound healing application. Materials & methods: Functionalization of
nanoceria were done with FA using a chemical method and their antibacterial activity, cellular
biocompatibility and in vivo wound healing application were evaluated. Results: The functionalization
of nanoceria with FA was done with 10 to 20 nm size and -20.1 mV zeta potential. The nanoformulation
showed a bacteriostatic effect along with biocompatibility to different cell lines; 0.1% w/v spray of
FA-nanoceria demonstrated excellent wound healing capacity within 14 days in a Wister rat model.
Conclusion: The antioxidant and reactive oxygen species scavenging activity of the FA-nanoceria make it a
promising therapeutic agent as a unique spray formulation in wound healing applications.