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Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer’s disease therapy - supplementary material

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posted on 2022-10-20, 11:39 authored by Sylvain Grosjean, Irene Pacho´ n-Angona, Michella Dawra, Bernard Refouvelet, Lhassane Ismaili

Graphical abstract 

 Table 1S. Multicomponent reactions (MCRs): reaction name and year of discovery. 

  

Figure 1S. Hantzsch 3-component reaction (H-3CR) leading to 1,4-dihydropyridine (1,4-DHP). 

  

Figure 2S. Biginelli 3-component reaction (B-3CR) leading to dihydropyrimidin-2-(thi)one (DHPM). 

  

Figure 3S. Ugi 4-component reaction (U-4CR) leading to bis-amide α-acylaminocarboxamide.


Funding

Regional Council of Bourgogne Franche Comté, (Grant / Award Number: '2022Y-13659 and 2022Y-13660')

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