Human Sirtuin 2 inhibitors, their mechanisms and binding modes - supplementary_material.docx

 Figure S1. LigPlotPlus ligand binding diagrams for human Sirtuin 2 (hSIRT2) substrates. 

  

Figure S2. LigPlotPlus ligand binding diagrams for human Sirtuin 2 (hSIRT2) reaction products.

  

Figure S3. LigPlotPlus ligand binding diagram for the EX243 human Sirtuin 2 (hSIRT2) enzymatic inhibitor.

  

Figure S4. LigPlotPlus ligand binding diagrams for human Sirtuin enzymatic inhibitors.

  

Figure S5. Representation of the human Sirtuin 2 (hSIRT2) structure bound to ligands.

  

Figure S6. Representation of the human Sirtuin 2 (hSIRT2) structure bound to ligands.

  

Figure S7. LigPlotPlus ligand binding diagram for a human Sirtuin 3 (hSIRT3) substrate and nicotinamide competitive inhibitor.

  

Figure S8. Representation of the human Sirtuin 2 (hSIRT2) structure bound to ligands.