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Human Sirtuin 2 inhibitors, their mechanisms and binding modes - supplementary_material.docx

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posted on 2023-03-09, 11:10 authored by Andre Berndt Penteado, Haifa Hassanie, Renan Augusto Gomes, Flavio da Silva Emery, Gustavo Henrique Goulart Trossini

 Figure S1. LigPlotPlus ligand binding diagrams for human Sirtuin 2 (hSIRT2) substrates. 

  

Figure S2. LigPlotPlus ligand binding diagrams for human Sirtuin 2 (hSIRT2) reaction products.

  

Figure S3. LigPlotPlus ligand binding diagram for the EX243 human Sirtuin 2 (hSIRT2) enzymatic inhibitor.

  

Figure S4. LigPlotPlus ligand binding diagrams for human Sirtuin enzymatic inhibitors.

  

Figure S5. Representation of the human Sirtuin 2 (hSIRT2) structure bound to ligands.

  

Figure S6. Representation of the human Sirtuin 2 (hSIRT2) structure bound to ligands.

  

Figure S7. LigPlotPlus ligand binding diagram for a human Sirtuin 3 (hSIRT3) substrate and nicotinamide competitive inhibitor.

  

Figure S8. Representation of the human Sirtuin 2 (hSIRT2) structure bound to ligands.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo, (Grant / Award Number: ) Conselho Nacional de Desenvolvimento Científico e Tecnológico, (Grant / Award Number: ) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, (Grant / Award Number: )

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