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Haem oxygenase-1 and haemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China: Supplementary figures 1 & 2

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posted on 26.04.2022, 09:25 by Wenpei Liu, Lihuan Lu, Hongqiu Pan, Xiaomin He, Meiling Zhang, Nannan Wang, Jia Zhu, Honggang Yi, Shaowen Tang

Objective: To assess whether the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) might be

influenced by haem oxygenase-1 (HMOX1) and haemopexin (HPX) gene polymorphisms. Methods: A

dynamic anti-tuberculosis treatment cohort was constructed, and the 1:4 matched nested case–control

study was analysed. Eight single nucleotide polymorphisms (SNPs) of the two genes were selected for

genotyping and Bonferroni correction was performed to correct for multiple comparison. Results: Overall,

7.8% of patients developed ATDH. SNP rs1807714 in the HMOX1 gene had decreased effects on the risk

of moderate and severe hepatotoxicity under the dominant and additive models, and hepatocellular

injury under the additive model. SNP rs2682099 in the HPX gene had increased effects on the risk of

moderate and severe hepatotoxicity under the recessive model. However, these associations disappeared

after Bonferroni correction. Conclusion: HMOX1 and HPX gene polymorphisms might not be associated

with susceptibility to ATDH in the Chinese population.

Funding

National Natural Science Foundation of China (grant no.: 82073614).

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