Haem oxygenase-1 and haemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China: Supplementary figures 1 & 2
Objective: To assess whether the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) might be
influenced by haem oxygenase-1 (HMOX1) and haemopexin (HPX) gene polymorphisms. Methods: A
dynamic anti-tuberculosis treatment cohort was constructed, and the 1:4 matched nested case–control
study was analysed. Eight single nucleotide polymorphisms (SNPs) of the two genes were selected for
genotyping and Bonferroni correction was performed to correct for multiple comparison. Results: Overall,
7.8% of patients developed ATDH. SNP rs1807714 in the HMOX1 gene had decreased effects on the risk
of moderate and severe hepatotoxicity under the dominant and additive models, and hepatocellular
injury under the additive model. SNP rs2682099 in the HPX gene had increased effects on the risk of
moderate and severe hepatotoxicity under the recessive model. However, these associations disappeared
after Bonferroni correction. Conclusion: HMOX1 and HPX gene polymorphisms might not be associated
with susceptibility to ATDH in the Chinese population.