|
Methylation
and gene expression levels of TRIM58 in pan-cancer
|
(A) Bubble charts
demonstrating significant correlations between TRIM58 expression and
methylation in pan-cancer samples. The correlation coefficient was determined
by Pearson’s correlation. (B) Differences in TRIM58 expression in normal and
tumor pan-cancer samples. (* represents for
p < 0.05, ** represent
for
p < 0.01, *** represent for
p < 0.001) (HNSC: Head and
Neck squamous cell carcinoma; CESC: Cervical squamous cell carcinoma and
endocervical adenocarcinoma; PRAD: Prostate adenocarcinoma; LUSC: Lung squamous
cell carcinoma; COAD: Colon adenocarcinoma; PAAD: Pancreatic adenocarcinoma;
LUAD: Lung adenocarcinoma; ESCA: Esophageal carcinoma; SKCM: Skin Cutaneous
Melanoma; UCEC: Uterine Corpus Endometrial Carcinoma; CHOL: Cholangiocarcinoma;
BLCA: Bladder Urothelial Carcinoma; KIRC: Kidney renal clear cell carcinoma;
LIHC: Liver hepatocellular carcinoma; THCA: Thyroid carcinoma; ACC:
Adrenocortical carcinoma; GBM: Glioblastoma multiforme; STAD: Stomach
adenocarcinoma; READ: Rectum adenocarcinoma).
(C) Immunohistochemical
staining for TRIM58 in breast cancer samples and other cancer types form the
HPA database. (D) Forest plots derived from univariate Cox regression analyses
highlighting TRIM58 methylation levels associated with OS in pan-cancer
samples. Hazard ratios and 95% confidence intervals are shown (* represents for
p < 0.05, ** represent for
p < 0.01).
