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Determination of favipiravir in human plasma using homogeneous liquid-liquid microextraction followed by HPLC/UV: Supplementary materials

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posted on 10.01.2022, 10:14 authored by Inas A. Abdallah, Sherin F. Hammadb, Alaa Bedaira, Ahmed H. Elshafeeyc, Fotouh R. Mansour

Figure S1: Light microscope images of SULLME using acetonitrile (left) and THF (right)

Figure S2: Effect of sugar type on the extraction efficiency of SULLME of favipiravir.

Figure S3: Chromatogram of blank plasma showing no interfering peaks at the retention periods of favipiravir and propranolol. Chromatographic conditions: Column: Thermo Hypersil ODS C18 (250 mm × 4.6 mm, 5 µm) at 30°C, Mobile phase: acetonitrile: phosphate buffer (50mM, pH 2.5) (40:60, v/v), Elution: Isocratic, Detection: UV at 323 nm, Flow rate: 1 mL/min, Injection volume: 5 µL.

Table S1: Comparison between the developed method and the reference LLE HPLC/UV method.