Design, synthesis and biological evaluation of novel selective PI3Kδ inhibitors containing pyridopyrimidine scaffold

Figure S1. Molecular docking studies of compound B1 into the site of PI3Kδ (PDB code: 2wxp). The distances of the hydrogen bonds are marked in the picture in Å

Table S1. Physicochemical and drug-likeness properties of A1, A5 and A7^a.

Table S2. Predicted ADME/T properties of A1, A5 and A7^a.

Figure S2. ¹H-NMR of compound A1. Figure S3. ¹³C-NMR of compound A1. Figure S4. ¹H-NMR of compound A2. Figure S5. ¹³C-NMR of compound A2. Figure S6. ¹H-NMR of compound A3. Figure S7. ¹³C-NMR of compound A3. Figure S8. ¹H-NMR of compound A4. Figure S9. ¹³C-NMR of compound A4.