Design, Synthesis, and Bio-evaluation of Indolin-2-ones as Potential Antidiabetic Agents - Supplementary material
Figure-S1: Structure-activity relationship (SAR) of compounds 1-10.
Figure-S2: Structure-activity relationship (SAR) of compounds 26-35.
Figure-S3: (A) Graph of compound 1; Lineweaver- Burk plot of reciprocal of rate of reaction (velocities) vs reciprocal of the substrate (p-nitrophenyl α-D-glucopyranoside) in the different concentrations of inhibitor (0, 0.625, 1.25 and 2.5 µM). Whereas Vmax and Km values were calculated from Lineweaver- Burk plot. (B) Compound 1; Dixon plot of reciprocal rate of reaction (velocities) vs different inhibitor concentrations (0, 0.625, 1.25 and 2.5 µM). Whereas the Ki value was calculated from the Dixon plot.