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Download fileDesign, Synthesis, and Bio-evaluation of Indolin-2-ones as Potential Antidiabetic Agents - Supplementary material
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posted on 2023-01-16, 09:48 authored by Itohowo Gabriel Asuquo, Mehwish Solangi, Khalid Mohammed Khan, Sridevi Chigurupati, Ifeanyi Edozie Otuokere, Francis Kalu Ekuma, Uzma Salar, Shatha Ghazi Felemban, Ashfaq Ur Rehman, Abdul Wadood, Muhammad Taha
Figure-S1: Structure-activity relationship (SAR) of compounds 1-10.
Figure-S2: Structure-activity relationship (SAR) of compounds 26-35.
Figure-S3: (A) Graph of compound 1; Lineweaver- Burk plot of reciprocal of rate of reaction (velocities) vs reciprocal of the substrate (p-nitrophenyl α-D-glucopyranoside) in the different concentrations of inhibitor (0, 0.625, 1.25 and 2.5 µM). Whereas Vmax and Km values were calculated from Lineweaver- Burk plot. (B) Compound 1; Dixon plot of reciprocal rate of reaction (velocities) vs different inhibitor concentrations (0, 0.625, 1.25 and 2.5 µM). Whereas the Ki value was calculated from the Dixon plot.
