Antitumor applications of polyphenol-conjugated turnip mosaic virus-derived nanoparticles nnm-2022-0067 Suppl figs

Background: Filamentous plant virus-derived nanoparticles are biodegradable and noninfectious to

humans. Their structure is also amenable to chemical modifications. They constitute an appealingmaterial

for biomedical applications including imaging and drug delivery. We had previously used turnip mosaic

virus-derived nanoparticles (TuMV-NPs) to increase antibody-sensing in vivo, to prevent biofilm formation

and to build biological nanoscaffolds. Materials & methods: We analyzed TuMV-NP biodistribution and

tumor homing using in vivo imaging.We studied in vitro the interaction with human cancer cell lines and

the antiproliferative effect of epigallocatechin gallate-functionalized TuMV-NPs. Results & conclusion:

TuMV-NPs are efficiently internalized by human cells and show good tumor homing. The antiproliferative

effect of epigallocatechin gallate-TuMV-NPs suggests that they could offer a potential anticancer therapy.