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Aminopyridone-linked benzimidazoles: a fragment-based drug design for the development of CDK9 inhibitors

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posted on 2023-08-16, 08:43 authored by Hamada S. Abulkhair, Ebtehal M Husseiny, Sanadelaslam SA El-Hddad, Nada Osama, Mona S. El-Zoghbi

Figure S1: Detection of apoptosis in MCF-7 cells processed with DMSO (at the left) and compound 6a (at the right)

Figure S2: MCF-7 Cell cycle analysis for compound 6a (on the left side) comparing with control (on the right side).

Table S1: Apoptotic and anti-apoptotic genes expression in MCF-7 cells for compound 6a

Table S2: Results of in silico of docking experiments of new compounds and the co-crystallized ligand (SLQ).

Spectral data All melting points were determined using Stuart digital melting point apparatus.

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