5-Fluorouracil-caffeic acid cocrystal delivery agent with long-term and synergistic high-performance antitumor effects - supplementary material

 Figure S1. An Ortep view of the cocrystal FL-CF-2H2O.  

 Figure S2. The simulated and experimental PXRD patterns of cocrystal FL-CF-2H2O. 

 Figure S3. MEP maps of FL, cocrystal FL-CF-2H2O and monomer carrier of PEG-PCL. 

 Figure S4. (a) and (b) are two geometrical structures and relative Eint values of FL and PEG-PCL binding in FL micelles, (c) and (d) correspond to two optimized configurations and relative Eint values of the cocrystal combined with PEG-PCL. 

 Figure S5. IR spectra of cocrystal FL-CF-2H2O, polymers PEG-PCL, and cocrystal-loaded micelles as well as the micelles co-loaded with FL and CF.