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pme-2020-0172 - Supplementary Table S2

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posted on 22.10.2021, 09:27 authored by Favela-Mendoza Alma Faviola, Rodríguez-Rodríguez Brenda Guadalupe, Rojas-Prado Eduardo, Chávez-Arreguin Mariana, Aguilar-Velázquez José Alonso, Martínez-Cortés Gabriela, Rangel-Villalobos Héctor

Supplementary Table S2. Fst p-values (above diagonal) and Fst genetic distances (below diagonal) among 14 populations for the SLCO1B1 gene variant rs4149056.

Aims. To evaluate the genetic distribution of the rs4149056 and rs2306283 variants into the SLCO1B1 gene in Mexican Mestizo (admixed) and Native American groups. Patients & Methods. We recruited 360 volunteers who were qPCR-genotyped with TaqMan probes. Results. Allele and genotype frequencies are reported. Among the expected rs4149056–rs2306283 haplotypes, T–A (42.35 to 58.47%) was the most prevalent which relates to the normal activity of the OATP1B1 transporter. This was followed by the T–G haplotype associated with further statin transport and cholesterol reduction (32.49 to 43.76%). Conclusions. Based on these SLCO1B1 gene variants, we confirmed that a minimum fraction of the Mexican study populations would be at risk from decreasing simvastatin transport, and the development of statin-induced myopathy.

Funding

Funding Universidad de Guadalajara PRO-SNI 2019

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