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pme-2020-0167 - Supplementary Material - A GRIN3A Polymorphism May be Associated with Glucocorticoid-Induced Symptomatic Osteonecrosis in Children with Acute Lymphoblastic Leukemia

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posted on 18.08.2021, 13:58 by Nathalie K. Zgheib, Habib El-Khoury, Dimitri Maamari, Maya Basbous, Raya Saab, Samar A. Muwakkit

Supplementary Table 1 Associations of combinations of genetic polymorphisms (allele carriers) with incidence of glucocorticoid-induced grade 4 osteonecrosis
Supplementary Table 2 Odds ratios (95% CI) of glucocorticoid-induced grade 4 osteonecrosis by genotype in intermediate/high risk arm only
Supplementary Table 3 Time (in weeks) to occurrence of glucocorticoid-induced grade 4 osteonecrosis by genotype in intermediate/high risk arm only

Supplementary Table 4 Dexamethasone (mg/m2) cumulative dose to glucocorticoid-induced grade 4 osteonecrosis by genotype in intermediate/high risk arm only

Supplementary Table 5 Hazard Ratios (95% CI) of time (weeks) and Dexamethasone (mg/m2) cumulative dose to occurrence of glucocorticoid-induced grade 4 osteonecrosis by genotype in intermediate/high risk arm only

Supplementary Figure 1 Cumulative incidence of glucocorticoid-induced grade 4 osteonecrosis in subjects treated with the intermediate/high risk arm by GRIN3A genotype with cumulative dexamethasone dose (P=0.039 by Log-rank test)

Funding

Funding American University of Beirut Faculty of Medicine Naef K. Basile Cancer Institute tumor registry and data base, and American University of Beirut Faculty of Medicine Medical Practice Plan

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