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bmm-2021-0579 supplementary materials

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posted on 25.04.2022, 08:30 by Yulia Liem, Andrew Judge, Yunfei LiYunfei Li, Mohammed Sharif

  

Abstract 

Aims: To identify prognostic biomarker(s) for knee OA in the osteoarthritis initiative (OAI) cohort. Methods: Multilevel regression was used to determine the association of baseline biomarkers and change in biomarker between baseline and 24-months, with clinical and radiographic OA progression over 48 months follow up. Results: Higher values of baseline uCTXII was consistently associated with an increased risk of OA disease progression outcomes:K&L grade (Odds Ratio (OR) 1.15 95% CI (1.03,1.28); medial JSN (OR 1.06 (1.02,1.10)); lateral osteophytes (OR 1.05 (1.01,1.10)); JSW (regression coefficient –0.005 (-0.008,-0.001)); WOMAC pain (OR 1.02 (1.01,1.04)). Changes in sPIIANP and sCOMP over 24 months were associated with clinical disease progression. Conclusion: uCTXII showed stronger associations with radiographic OA and appear to be a reliable prognostic marker while changes in other biomarkers were found in early symptomatic OA supporting the phasic nature of OA.

Funding

Higher Education Funding Council for England

Joint China Scholarship Council-University of Bristol Scholarship Scheme

Versus Arthritis

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