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Tumor vascular heterogeneity and the impact of sub-tumoral nanoemulsion biodistribution - Supplementary dataset

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posted on 2023-02-28, 15:34 authored by Jaqueline Vaz de Oliveira, Marcia Cristina Oliveira da Rocha, Ailton Antonio de Sousa-Junior, Mosar Corrêa Rodrigues, Gabriel Ribeiro Farias, Patrıcia Bento da Silva, Sonia Nair Bao, Andris Figueiroa Bakuzis, Ricardo Bentes Azevedo, Paulo Cesar Morais, Luıs Alexandre Muehlmann, Joao Paulo Figueiro Longo

Aim: Investigate the heterogeneous tumor tissue organization and examine how this condition can

interfere with the passive delivery of a lipid nanoemulsion in two breast cancer preclinical models

(4T1 and Ehrlich). Materials & methods: The authors used in vivo image techniques to follow the

nanoemulsion biodistribution and microtomography, as well as traditional histopathology and electron

microscopy to evaluate the tumor structural characteristics. Results & conclusion: Lipid nanoemulsion

was delivered to the tumor, vascular organization depends upon the subtumoral localization and this

heterogeneous organization promotes a nanoemulsion biodistribution to the highly vascular peripherical

region. Also, the results are presented with a comprehensive mathematical model, describing the

differential biodistribution in two different breast cancer models, the 4T1 and Ehrlich models.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico, (Grant / Award Number: '303182/2019-9')

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, (Grant / Award Number: '01')

Fundação de Apoio à Pesquisa do Distrito Federal, (Grant / Award Number: '00193-00000734/2021-75','00193.00001053/2021-24')

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