Future Science Group
Browse
Supplementary Table 1S.docx (13.6 kB)

Therapeutic outcome of quercetin nanoparticles on Cerastes cerastes venom-induced hepatorenal toxicity: a preclinical study - supplementary table

Download (13.6 kB)
dataset
posted on 2023-04-26, 10:25 authored by Kahina Kiouas, Habiba Oussedik-Oumehdi, Fatima Laraba-Djebari

Aim: The objective of this study was to investigate the therapeutic potential of quercetin (QT) and

QT-loaded poly(lactic-co-glycolic acid) nanoparticles (QT-NPs) on Cerastes cerastes venom-mediated

inflammation, redox imbalance, hepatorenal tissue damage and local hemorrhage. Methods: The

developed QT-NPs were first submitted to physicochemical characterization and then evaluated in the

‘challenge then treat’ and ‘preincubation’ models of envenoming. Results: QT-NPs efficiently alleviated

hepatorenal toxicity, inflammation and redox imbalance and significantly attenuated venom-induced

local hemorrhage. Interestingly, QT-NPs were significantly more efficient than free QT at 24 h postenvenoming,

pointing to the efficacy of this drug-delivery system. Conclusion: These findings highlight

the therapeutic potential of QT-NPs on venom-induced toxicity and open up the avenue for their use in

the management of snakebite envenoming.

History

Usage metrics

    Nanomedicine

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC