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The efficacy of antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis: supplementary materials

posted on 2023-05-16, 10:53 authored by Kaneez Fatima, Muhammad Aemaz Ur Rehman, Abyaz Asmar, Hareem Farooq, Noor-Us-Sabah Ahmad, Ahmad Danial, Muhammad Ebaad Ur Rehman, Abdullah Ali Khan, Sidra Tahir, Umair Ahmed, Salman Zubair, Ayaz Khawaja

Aim: The efficacy of antifibrinolytics in subarachnoid hemorrhage remains unclear due to conflicting

evidence from studies. Materials & methods: Online databases were queried to include randomized

controlled trials and propensitymatched observational studies.We used ReviewManager for the statistical

analysis, presenting results as odds ratios with 95% CI. Results: The 12 shortlisted studies included 3359

patients, of which 1550 (46%) were in the intervention (tranexamic acid) group and 1809 (54%) in the

control group. Antifibrinolytic therapy significantly reduced the risk of rebleeding (OR: 0.55; 95% CI:

0.40–0.75; p = 0.0002) with no significant decrease in poor clinical outcome (OR: 1.02; 95% CI: 0.86–

1.20; p = 0.85) and all-cause mortality (OR: 0.92; CI: 0.72–1.17; p = 0.50). Conclusion: In patients with

subarachnoid hemorrhage, antifibrinolytics reduce the risk of rebleeding without significantly affecting

mortality or clinical outcomes.