Synthesis of hydrazinylthiazole carboxylates: a mechanistic approach for treatment of diabetes and its complications

The inhibition potential of compounds 3a–n was found to be dose-dependent, as shown in Supplementary Table 2.

Compounds 3a–n were tested for their in vitro antiglycation activity using aminoguanidine as reference inhibitor (Supplementary Table 3).

The free radical scavenging ability of compounds 3a–n was estimated using the DPPH scavenging model. Ascorbic acid was used as positive control, and percentage antioxidant ability and IC50 values are presented in Supplementary Table 4.