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Synthesis of hydrazinylthiazole carboxylates: a mechanistic approach for treatment of diabetes and its complications

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posted on 2023-08-08, 09:46 authored by Hasnain Mehmood, Tashfeen Akhtar, Muhammad Haroon, Muhammad Shah, Umer Rashid, Simon Woodward

The inhibition potential of compounds 3a–n was found to be dose-dependent, as shown in Supplementary Table 2.

Compounds 3a–n were tested for their in vitro antiglycation activity using aminoguanidine as reference inhibitor (Supplementary Table 3).

The free radical scavenging ability of compounds 3a–n was estimated using the DPPH scavenging model. Ascorbic acid was used as positive control, and percentage antioxidant ability and IC50 values are presented in Supplementary Table 4.